Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease.

The Journal of biological chemistry - 16 Jul 2004

Banno Fumiaki, Kaminaka Kazuyoshi, Soejima Kenji, Kokame Koichi, Miyata Toshiyuki

Abstract excerpt

Human ADAMTS13 was recently identified as a gene encoding von Willebrand factor-cleaving protease, hADAMTS13. Both congenital and acquired defects in this enzyme can cause thrombotic thrombocytopenic purpura. hADAMTS13 consists of 1,427 amino acid residues and is composed of multiple structural domains including thrombospondin type 1 motifs and CUB domains. To analyze the functional roles of these domains in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAMTS13 Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Northern

Share to Metalloendopeptidases

Share to Mice, Inbred C3H

Share to Mice, Inbred DBA

Share to Mice, Inbred ICR

Share to Thrombospondins

Source

Identifiers

PMID: 15136581
DOI: 10.1074/jbc.M314184200

Genes

ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease.PMID 15136581Read ↗

An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.Semantic proximity Read ↗

The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formationSemantic proximity Read ↗

Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.Semantic proximity Read ↗

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.Semantic proximity Read ↗

Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract developmentSemantic proximity Read ↗

The endothelial-specific regulatory mutation, Mvwf1, is a common mouse founder allele.Semantic proximity Read ↗

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo.Semantic proximity Read ↗

Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activitySemantic proximity Read ↗

Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23Semantic proximity Read ↗

ADAMTS13 assays and ADAMTS13-deficient mice.Semantic proximity Read ↗

Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organizationSemantic proximity Read ↗

Mouse Chromosome 17A3.3 Contains 13 Genes That Encode Functional Tryptic-like Serine Proteases with Distinct Tissue and Cell Expression PatternsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.