Article
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics.
Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2000
Dubail Johanne, Apte Suneel S
Abstract excerpt
The mammalian ADAMTS superfamily comprises 19 secreted metalloproteinases and 7 ADAMTS-like proteins, each the product of a distinct gene. Thus far, all appear to be relevant to extracellular matrix function or to cell-matrix interactions. Most ADAMTS functions first emerged from analysis of spontaneous human and animal mutations and genetically engineered animals. The clinical manifestations of Mendelian...
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