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Article

Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization

4 Feb 2005

Abstract excerpt

BACKGROUND: The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue...

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PMID: 15693998
DOI: 10.1186/1471-2148-5-11

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