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Article

An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.

Blood - 1 Aug 2007

Zhou Wenhua, Bouhassira Eric E, Tsai Han-Mou

Abstract excerpt

Severe deficiency of ADAMTS13, a von Willebrand factor (VWF)-cleaving metalloprotease, causes thrombotic thrombocytopenic purpura. When analyzed with VWF multimers, but not with an abbreviated VWF peptide (VWF73) as the substrate, the plasma ADAMTS13 activity levels of mouse strains segregated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17426255
DOI: 10.1182/blood-2007-01-070953
PMCID: PMC1924774

Genes

ADAMTS13
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17426255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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An IAP retrotransposon in the mouse ADAMTS13 gene creates ADAMTS13 variant proteins that are less effective in cleaving von Willebrand factor multimers.PMID 17426255Read ↗

Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease.Semantic proximity Read ↗

Expression of a structurally constrained von Willebrand factor variant triggers acute thrombotic thrombocytopenic purpura in mice.Semantic proximity Read ↗

ADAMTS13 assays and ADAMTS13-deficient mice.Semantic proximity Read ↗

Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.Semantic proximity Read ↗

Mutation and ADAMTS13-dependent modulation of disease severity in a mouse model for von Willebrand disease type 2BSemantic proximity Read ↗

The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formationSemantic proximity Read ↗

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo.Semantic proximity Read ↗

Use of a mouse model to elucidate the phenotypic effects of the von Willebrand factor cleavage mutants, Y1605A/M1606A and R1597W.Semantic proximity Read ↗

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13Semantic proximity Read ↗

Identifying novel genetic determinants of hemostatic balance.Semantic proximity Read ↗

von Willebrand factor propeptide to antigen ratio identifies platelet activation and reduced von Willebrand factor survival phenotype in mice.Semantic proximity Read ↗

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease.Semantic proximity Read ↗

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