Article
Microtubule-associated protein light chain 2 is a stargazin-AMPA receptor complex-interacting protein in vivo.
The Journal of biological chemistry - 23 Jul 2004
Ives Jane H, Fung Susanna, Tiwari Priyanka, Payne Helen L, Thompson Christopher L
Abstract excerpt
The ataxic mutant mouse stargazer is a null mutant for stargazin, a protein involved in the regulation of cell surface trafficking and synaptic targeting of AMPA receptors. The extreme C terminus of stargazin (sequence, -TTPV), confers high affinity for PDZ domain-containing proteins e.g. PSD-95. Interaction with PDZ proteins enables stargazin to fulfill its role as an AMPA receptor synaptic targeting molecule...
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