Article
GISP binding to TSG101 increases GABA receptor stability by down-regulating ESCRT-mediated lysosomal degradation.
Journal of neurochemistry - 1 Oct 2008
Kantamneni Sriharsha, Holman David, Wilkinson Kevin A, Corrêa Sônia A L, Feligioni Marco, Ogden Simon, Fraser William, Nishimune Atsushi, Henley Jeremy M
Abstract excerpt
The neuron-specific G protein-coupled receptor interacting scaffold protein (GISP) is a multidomain, brain-specific protein derived from the A-kinase anchoring protein-9 gene. We originally isolated GISP as an interacting partner for the GABA(B) receptor subunit GABA(B1). Here, we show that the protein tumour susceptibility gene 101 (TSG101), an integral component of the endosomal sorting machinery that targets...
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