Article
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability.
Molecular psychiatry - 1 May 2022
Caldeira G L, Inácio A S, Beltrão N, Barreto C A V, Rodrigues M V, Rondão T, Macedo R, Gouveia R P, Edfawy M, Guedes J, Cruz B, Louros S R, Moreira I S, Peça J, Carvalho A L
Abstract excerpt
Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse. Transmembrane AMPA receptor regulatory proteins (TARPs) are AMPA receptor auxiliary proteins that regulate crucial aspects of receptor function. Here, we investigate a mutant form of the TARP family member stargazin, described in an ID patient....
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