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Article

Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse.

Brain research - 3 Jan 2012

Shevtsova Olga, Leitch Beulah

Abstract excerpt

AMPA receptor subunits (GluA1-4) are trafficked to membrane synaptic sites by transmembrane AMPA receptor regulatory proteins (TARPs). In the stargazer mutant mouse, expression of TARP-γ2 (stargazin) is severely reduced, resulting in cerebellar ataxia. Stargazer granule cells (GCs) have a complete loss of functional AMPARs, as γ2 is their main TARP; hence mossy fiber (MF)-GC synapses are silent. The aim of the...

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Source

Identifiers

PMID: 22055455
DOI: 10.1016/j.brainres.2011.10.022

Genes

TARP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse.PMID 22055455Read ↗

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