Article
Learning from stargazin: the mouse, the phenotype and the unexpected.
Current opinion in neurobiology - 1 Jun 2006
Osten Pavel, Stern-Bach Yael
Abstract excerpt
The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges. Stargazin is related to the gamma-1 subunit of skeletal muscle voltage-dependent calcium channel (VDCC), and a deficit in its role as auxiliary VDCC subunit was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
