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Article

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 2002

Schnell Eric, Sizemore Max, Karimzadegan Siavash, Chen Lu, Bredt David S, Nicoll Roger A

Abstract excerpt

Excitatory synapses in the brain exhibit a remarkable degree of functional plasticity, which largely reflects changes in the number of synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). However, mechanisms involved in recruiting AMPARs to synapses are unknown. H...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12359873
DOI: 10.1073/pnas.172511199
PMCID: PMC129795

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12359873-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number.PMID 12359873Read ↗

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Stargazin interacts functionally with the AMPA receptor glutamate-binding module.Semantic proximity Read ↗

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Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.Semantic proximity Read ↗

Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution.Semantic proximity Read ↗

Selective loss of AMPA receptor subunits at inhibitory neuron synapses in the cerebellum of the ataxic stargazer mouse.Semantic proximity Read ↗

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