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Article

Mutagen Synergy: Hypermutability Generated by Specific Pairs of Base Analogs.

Journal of bacteriology - 15 Oct 2016

Ang Jocelyn, Song Lisa Yun, D'Souza Sara, Hong Irene L, Luhar Rohan, Yung Madeline, Miller Jeffrey H

Abstract excerpt

UNLABELLED: We tested pairwise combinations of classical base analog mutagens in Escherichia coli to study possible mutagen synergies. We examined the cytidine analogs zebularine (ZEB) and 5-azacytidine (5AZ), the adenine analog 2-aminopurine (2AP), and the uridine/thymidine analog 5-bromodeoxyuridine (5BrdU). We detected a striking synergy with the 2AP plus ZEB combination, resulting in hypermutability, a...

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Identifiers

PMID: 27457718
DOI: 10.1128/JB.00391-16
PMCID: PMC5038009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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