Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Implications of proteasome inhibition: an enhanced macrophage phenotype.

Cellular immunology - 1 Feb 2004

Cuschieri Joseph, Gourlay David, Garcia Iris, Jelacic Sandra, Maier Ronald V

Abstract excerpt

The objective of this study was to elucidate the role of the cellular proteasome on endotoxin-mediated activation of the macrophage. To study this role, THP-1 cells were stimulated with lipopolysaccharide (LPS) with selective cells being pretreated with the proteasome inhibitor, lactacystin or MG-132. LPS stimulation led to the phosphorylation and degradation of IRAK, followed by activation of JNK/SAPK, ERK 1/2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cysteine Endopeptidases
Share to Endotoxins
Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-1 Receptor-Associated Kinases

Share to Interleukin-8

Share to Macrophage Activation

Share to Multienzyme Complexes

Share to Transcription Factor AP-1

Source

Identifiers

PMID: 15135296
DOI: 10.1016/j.cellimm.2004.03.005

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Implications of proteasome inhibition: an enhanced macrophage phenotype.PMID 15135296Read ↗

Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-gamma and lipopolysaccharide.Semantic proximity Read ↗

Up-regulation of PSMB4 is associated with neuronal apoptosis after neuroinflammation induced by lipopolysaccharide.Semantic proximity Read ↗

Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype.Semantic proximity Read ↗

Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.Semantic proximity Read ↗

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.Semantic proximity Read ↗

Both Erk and p38 Kinases Are Necessary for Cytokine Gene TranscriptionSemantic proximity Read ↗

Lipopolysaccharide-induced tumor necrosis factor-alpha promoter activity is inhibitor of nuclear factor-kappaB kinase-dependent.Semantic proximity Read ↗

Modulation of immunoproteasome subunits by liposomal lipid A.Semantic proximity Read ↗

Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway.Semantic proximity Read ↗

Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway.Semantic proximity Read ↗

Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.Semantic proximity Read ↗

Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.