Article
Modulation of immunoproteasome subunits by liposomal lipid A.
Vaccine - 2 Jun 2008
Steers Nicholas J, Alving Carl R, Rao Mangala
Abstract excerpt
Liposomes are phospholipid vesicles that have been used as carriers of antigens and adjuvants. Lipid A, the endotoxic moiety of Gram-negative bacterial lipopolysaccharide is a potent adjuvant and incorporation into liposomes essentially reduces the endotoxic activity of lipid A. In this study, we analyzed the effect of liposomal lipid A [L(LA)] on the MHC class I antigen processing machinery in murine antigen...
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