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Article

Both Erk and p38 Kinases Are Necessary for Cytokine Gene Transcription

1 Apr 1999

Abstract excerpt

A critical feature of sepsis-induced acute lung injury is the release of cytokines from endotoxin (LPS)- stimulated alveolar macrophages (AM). LPS is also known to activate various members of the mitogen- activated protein kinase (MAPK) family in other types of cells. In this study, we evaluated whether multiple members of the MAPK family regulate cytokine gene expression in LPS-stimulated AM. We found that LPS...

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PMID: 10101008
DOI: 10.1165/ajrcmb.20.4.3420

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