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Article

Proteasome-mediated proteolysis of the interleukin-10 receptor is important for signal downregulation.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 May 2006

Wei Sherry H-Y, Ming-Lum Andrew, Liu Ying, Wallach David, Ong Christopher J, Chung Stephen W, Moore Kevin W, Mui Alice L-F

Abstract excerpt

The cytokine interleukin-10 (IL-10) is an important regulator of immune cell function, proliferation, and survival. The IL-10 receptor (IL-10R) consists of two subunits, IL-10R1 and IL-10R2, both belonging to the class II cytokine receptor superfamily. Like other members of the cytokine receptor superfamily, IL-10R stimulation leads to activation of Jak family kinases and Stat transcription factors. To identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16689656
DOI: 10.1089/jir.2006.26.281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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