Article
Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.
Nature - 16 Sept 1993
Gaczynska M, Rock K L, Goldberg A L
Abstract excerpt
The presentation of intracellular proteins to the immune system requires their degradation to small peptides that then become associated with major histocompatibility complex (MHC) class I molecules. The generation of these peptides may involve the 20S or 26S proteasome particles, which contain m...
Topics
- Amino Acid Sequence
- Cell Line
- Cysteine Endopeptidases
- Gene Expression
- Histocompatibility Antigens Class I
- Humans
- Hydrolysis
- Interferon-gamma
- Major Histocompatibility Complex
- Molecular Sequence Data
- Monocytes
- Multienzyme Complexes
- Mutation
- Peptides
- Proteasome Endopeptidase Complex
- Proteins
- Ubiquitins