Article
Inducible nitric-oxide synthase is regulated by the proteasome degradation pathway.
The Journal of biological chemistry - 29 Jun 2001
Musial A, Eissa N T
Abstract excerpt
Inducible nitric-oxide synthase (iNOS) is responsible for nitric oxide (NO) synthesis from l-arginine in response to inflammatory mediators. To determine the degradation pathway of iNOS, human epithelial kidney HEK293 cells with stable expression of human iNOS were incubated in the presence of various degradation pathway inhibitors. Treatment with the proteasomal inhibitors lactacystin, MG132, and...
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