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Article

Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype.

PloS one - 1 Jan 2015

Na Yi Rang, Yoon Yi Na, Son Dain, Jung Daun, Gu Gyo Jeong, Seok Seung Hyeok

Abstract excerpt

Macrophages play important roles in defense against infection, as well as in homeostasis maintenance. Thus alterations of macrophage function can have unexpected pathological results. Cyclooxygenase (COX) inhibitors are widely used to relieve pain, but the effects of long-term usage on macrophage...

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Identifiers

PMID: 25680189
DOI: 10.1371/journal.pone.0118203
PMCID: PMC4334507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25680189-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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