Article
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane.
FEBS letters - 7 May 2004
Imura Akihiro, Iwano Akiko, Tohyama Osamu, Tsuji Yoshihito, Nozaki Kazuhiko, Hashimoto Nobuo, Fujimori Toshihiko, Nabeshima Yo-Ichi
Abstract excerpt
Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed. Newly established antibodies against Klotho allowed the detection of secreted Klotho, a candidate for the putative humoral factor, in sera and cerebrospinal fluid. Surprisingly the secreted Klotho was 130...
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