Article
Association of plasma docetaxel levels with ABCB1 gene polymorphisms and tumour response in locally advanced breast cancer patients of South India on neo-adjuvant chemotherapy.
Breast cancer (Tokyo, Japan) - 1 Mar 2021
Priyadarshini Rekha, Raj Gerard Marshall, Sundaram Rajan, Kayal Smita, Ramesh Ananthakrishnan, Shewade Deepak Gopal
Abstract excerpt
BACKGROUND: Genetic factors could be attributed to the variability in docetaxel plasma levels and its subsequent therapeutic response. The objectives of this study were to assess the effect of ABCB1 gene polymorphisms [SNPs rs1045642 (C3435T) and rs1128503 (C1236T)] on docetaxel plasma levels and also to analyze the influence of docetaxel plasma levels on tumour response in the ethnically distinct South Indian...
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