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Article

An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival.

Oncogene - 22 Jul 2004

Edinger Aimee L, Thompson Craig B

Abstract excerpt

In yeast, TOR couples cellular growth and metabolism to the availability of extracellular nutrients. In contrast, mammalian TOR kinase activity has been reported to be regulated by growth factor stimulation via the PI3K/Akt pathway. Consistent with this, growth factor deprivation results in dephosphorylation of the mTOR target proteins p70S6k and 4EBP1 in the face of abundant extracellular nutrients. To determine...

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Identifiers

PMID: 15133498
DOI: 10.1038/sj.onc.1207738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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