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Article

The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

18 Nov 2021

Abstract excerpt

The tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth...

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PMID: 34869377
DOI: 10.3389/fcell.2021.775507

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