Article

mTOR dependent transformed human cells have a distinct set of essential genes from bcr-abl transformed cells

2019-08-16

Abstract excerpt

Constitutively active intracellular signaling drives and sustains cancer growth. The mTOR kinase integrates multiple inputs sensing nutrient, energy and growth factor levels to promote protein synthesis and anabolic metabolism, and is hyperactivated in a broad range of cancers. The bcr-abl kinase is a fusion protein generated by chromosomal translocation and gives rise to chronic myeloid leukemia and a small sub-s...

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Literature Corpus work: dacae043-11d9-5548-909d-b15feb6e18a5
DOI: 10.1101/737817

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