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Article

Isolation of hyperactive mutants of mammalian target of rapamycin.

The Journal of biological chemistry - 14 Nov 2008

Ohne Yoichiro, Takahara Terunao, Hatakeyama Riko, Matsuzaki Tomoko, Noda Makoto, Mizushima Noboru, Maeda Tatsuya

Abstract excerpt

The mammalian target of rapamycin (mTOR) is a Ser/Thr kinase that plays essential roles in the regulation of a wide array of growth-related processes such as protein synthesis, cell sizing, and autophagy. mTOR forms two functionally distinct complexes, termed the mTOR complex 1 (mTORC1) and 2 (mTORC2); only the former of which is inhibited by rapamycin. Based on the similarity between the cellular responses...

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Identifiers

PMID: 18812319
DOI: 10.1074/jbc.M801546200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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