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Article

Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin.

Molecular cancer therapeutics - 1 Mar 2014

Salloum Darin, Mukhopadhyay Suman, Tung Kaity, Polonetskaya Aleksandra, Foster David A

Abstract excerpt

The conversion of normal cells to cancer cells involves a shift from catabolic to anabolic metabolism involving increased glucose uptake and the diversion of glycolytic intermediates into nucleotides, amino acids, and lipids needed for cell growth. An underappreciated aspect of nutrient uptake is the utilization of serum lipids. We investigated the dependence of human cancer cells on serum lipids and report here...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24435447
DOI: 10.1158/1535-7163.MCT-13-0762
PMCID: PMC4001122

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