Article
Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.
Cell death and differentiation - 1 Sept 2004
Tainton K M, Smyth M J, Jackson J T, Tanner J E, Cerruti L, Jane S M, Darcy P K, Johnstone R W
Abstract excerpt
P-glycoprotein (P-gp) can induce multidrug resistance (MDR) through the ATP-dependent efflux of chemotherapeutic agents. We have previously shown that P-gp can inhibit nondrug apoptotic stimuli by suppressing the activation of caspases. To determine if this additional activity is functionally linked to ATP hydrolysis, we expressed wild-type and ATPase-mutant P-gp and showed that cells expressing mutant P-gp could...
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