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Article

The molecular basis of multidrug resistance in cancer: The early years of P‐glycoprotein research

28 Dec 2005

Abstract excerpt

The discovery and characterization of P-glycoprotein, an energy-dependent multidrug efflux pump, as a mechanism of multidrug resistance in cancer is generally accepted as a significant contribution to the ongoing effort to end death and suffering from this disease. The historical reflections of Victor Ling and Michael Gottesman concerning the early years of this research highlight the important contributions of...

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PMID: 16405967
DOI: 10.1016/j.febslet.2005.12.060

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