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The neurobiology of depression—revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies <sup/>

25 Feb 2013

Abstract excerpt

The serotonin system originates from a small number of neurons (a few hundred thousand of the 100 billion in man) located in the midbrain raphe nuclei, that project widely throughout the central nervous system to influence a large array of inter-related biological functions, not least of which are circuits involved in mood and emotion. The serotonin hypothesis of depression has postulated that a reduction in...

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PMID: 23440469
DOI: 10.1098/rstb.2012.0535

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