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Article

The neurobiology of depression—revisiting the serotonin hypothesis. I. Cellular and molecular mechanisms

23 Jul 2012

Abstract excerpt

The serotonin (5-HT) hypothesis of depression dates from the 1960s. It originally postulated that a deficit in brain serotonin, corrected by antidepressant drugs, was the origin of the illness. Nowadays, it is generally accepted that recurring mood disorders are brain diseases resulting from the combination, to various degrees, of genetic and other biological as well as environmental factors, evolving through the...

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PMID: 22826338
DOI: 10.1098/rstb.2012.0190

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