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Article

Phosphorylation, protein kinases and ADPKD.

Biochimica et biophysica acta - 1 Oct 2011

Li Xiaohong

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by renal cyst formation and caused by mutations in the PKD1 and PKD2 genes, which encode polycystin-1(PC-1) and -2 (PC-2) proteins, respectively. PC-1 is a large plasma membrane receptor involved in the regulation of several biological functions and signaling pathways including the Wnt cascade, AP-1, PI3kinase/Akt, GSK3β,...

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Source

Identifiers

PMID: 21392577
DOI: 10.1016/j.bbadis.2011.03.001

Genes

PKD1
PKD2
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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