Article

Development of a New and Improved Guanidine-based Rac1 Inhibitor with in Vivo Activity against Non-Small Cell Lung Cancer

2020-09-16

Abstract excerpt

Rac1 (Ras-related C3 botulinum toxin substrate 1), is a member of the family of Rho GTPases involved in the dynamic control of cytoskeleton reorganization and other fundamental cellular functions including growth, motility and survival. Aberrant activity of Rac1 and its regulators is common in human cancer. In particular, deregulated expression/activity of Rac Guanine nucleotide Exchange Factors (GEFs), respo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06ccac76-1da3-5445-bfc2-7665f741b6f4
DOI: 10.26434/chemrxiv.12950309.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of a New and Improved Guanidine-based Rac1 Inhibitor with in Vivo Activity against Non-Small Cell Lung CancerDOI 10.26434/chemrxiv.12950309.v1Read

Rational design and applications of a Rac GTPase-specific small molecule inhibitor.Semantic proximity Read

A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancerSemantic proximity Read

Bioinformatic analysis of RHO family of GTPases identifies RAC1 pharmacological inhibition as a new therapeutic strategy for hepatocellular carcinomaSemantic proximity Read

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.Semantic proximity Read

Pyrrole-based EGFR inhibitors for the treatment of NCSLC: Binding modes and SARs investigations.Semantic proximity Read

Identification of a new inhibitor of Ran GTPase with potential therapeutic value in epithelial ovarian cancerSemantic proximity Read

Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure–Activity Relationship (SAR)Semantic proximity Read

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer.Semantic proximity Read

Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.Semantic proximity Read

An Arf1 GTPase mutant with different responses to GEF inhibitors.Semantic proximity Read

4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.Semantic proximity Read

Structure-activity studies on arylamides and arysulfonamides Ras inhibitors.Semantic proximity Read