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Article

Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2004

Ono Hisae, Shirakawa Osamu, Nushida Hideyuki, Ueno Yasuhiro, Maeda Kiyoshi

Abstract excerpt

Suicide has been suggested to involve catecholaminergic dysfunction and to be related to genetics. Catechol-O-methyltransferase (COMT) 158Val/Met polymorphism (GenBank Accession No. Z26491) is a polymorphism of the gene encoding COMT, a major enzyme in catecholamine inactivation. The COMT 158Val/Met polymorphism affects COMT activity, that is, the alleles encoding Val and Met are associated with relatively high...

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Source

Identifiers

PMID: 15127078
DOI: 10.1038/sj.npp.1300470

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association between catechol-O-methyltransferase functional polymorphism and male suicide completers.PMID 15127078Read ↗

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