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Article

Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Dec 2007

Kia-Keating Brett M, Glatt Stephen J, Tsuang Ming T

Abstract excerpt

Several studies have suggested that suicidal behavior is at least partially determined by genetic factors, supporting a search for related genes. Two genes that have been highlighted in the literature as being involved are HTR1B, which codes for the serotonin 1B receptor, and COMT, which is related to the inactivation of catecholamines. In order to assess the combined evidence for the numerous studies that have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17525973
DOI: 10.1002/ajmg.b.30551

Genes

COMT

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Related research

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Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior.PMID 17525973Read ↗

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Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

Association of 5HTR1A gene variants with suicidal behavior: case-control study and updated meta-analysis.Semantic proximity Read ↗

Association of the 5HTR2A gene with suicidal behavior: case-control study and updated meta-analysis.Semantic proximity Read ↗

No association between the HTR1A gene and suicidal behavior: a meta-analysis.Semantic proximity Read ↗

No association of COMT Val158Met polymorphism with suicidal behavior or CSF monoamine metabolites in mood disorders.Semantic proximity Read ↗

The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder--a European multicenter study.Semantic proximity Read ↗

A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.Semantic proximity Read ↗

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