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Article

Catechol-O-methyltransferase Val158Met polymorphism and altered COMT gene expression in the prefrontal cortex of suicide brains.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Apr 2014

Du Lisheng, Merali Zul, Poulter Michael O, Palkovits Miklós, Faludi Gábor, Anisman Hymie

Abstract excerpt

Catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamine neurotransmitters within the brain. A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. In the present study we examined whether this polymorphism was related to COMT mRNA expression in frontal cortical regions, and whether the expression of COMT differed...

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Source

Identifiers

PMID: 24389396
DOI: 10.1016/j.pnpbp.2013.12.016

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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