Article
The association between catechol-O-methyl-transferase Val108/158Met polymorphism and suicide.
Genes, brain, and behavior - 1 Jul 2011
Pivac N, Pregelj P, Nikolac M, Zupanc T, Nedic G, Muck Seler D, Videtic Paska A
Abstract excerpt
One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catechol-O-methyl-transferase (COMT). It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders...
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