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Article

A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.

Biological psychiatry - 1 Jul 2003

Rujescu Dan, Giegling Ina, Gietl Anton, Hartmann Annette M, Möller Hans-Jürgen

Abstract excerpt

BACKGROUND: Suicidal behavior is often correlated with other-directed aggression, which is partially mediated by catecholaminergic neurotransmission. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine inactivation. In this study, we examined the influence of a functional COMT (V158M) polymorphism on suicidal behavior and anger-related traits. METHODS: This polymorphism was examined in 149...

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Source

Identifiers

PMID: 12842306
DOI: 10.1016/s0006-3223(02)01831-0

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A functional single nucleotide polymorphism (V158M) in the COMT gene is associated with aggressive personality traits.PMID 12842306Read ↗

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