Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone.

doi:10.1210/jc.2003-031640

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Article

Large-scale analysis of the relationship between CYP11A promoter variation, polycystic ovarian syndrome, and serum testosterone.

The Journal of clinical endocrinology and metabolism - 1 May 2004

Gaasenbeek Michelle, Powell Brenda L, Sovio Ulla, Haddad Lema, Gharani Neda, Bennett Amanda, Groves Christopher J, Rush Karen, Goh Micaela J, Conway Gerard S, Ruokonen Aimo, Martikainen Hannu, Pouta Anneli, Taponen Saara, Hartikainen Anna-Liisa, Halford Stephanie, Järvelin Marjo-Riitta, Franks Steve, McCarthy Mark I

Abstract excerpt

CYP11A, the gene encoding p450scc, a key enzyme in steroid biosynthesis, is a strong biological candidate for polycystic ovary syndrome (PCOS) susceptibility. Four of the five published studies that have examined CYP11A for evidence of linkage and/or association have reported significant relationships with polycystic ovary (PCO) status and/or serum testosterone levels. However, study sizes have been modest, and...

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PMID: 15126571
DOI: 10.1210/jc.2003-031640

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