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Article

Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis.

Cancer research - 15 May 2009

Russo Maria Teresa, De Luca Gabriele, Casorelli Ida, Degan Paolo, Molatore Sara, Barone Flavia, Mazzei Filomena, Pannellini Tania, Musiani Piero, Bignami Margherita

Abstract excerpt

Mismatch repair is the major pathway controlling genetic stability by removing mispairs caused by faulty replication and/or mismatches containing oxidized bases. Thus, inactivation of the Msh2 mismatch repair gene is associated with a mutator phenotype and increased cancer susceptibility. The base excision repair gene Mutyh is also involved in the maintenance of genomic integrity by repairing premutagenic lesions...

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Source

Identifiers

PMID: 19435918
DOI: 10.1158/0008-5472.CAN-08-3292

Genes

MSH2
MUTYH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of MUTYH and MSH2 in the control of oxidative DNA damage, genetic instability, and tumorigenesis.PMID 19435918Read ↗

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