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Article

The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese.

Journal of the neurological sciences - 15 May 2008

Wang Binbin, Wang Jing, Zhou Sirui, Tan Sainan, He Xiang, Yang Ze, Xie Yan-Chen, Li Shu, Zheng Chenguang, Ma Xu

Abstract excerpt

A functional polymorphism of mitochondrial aldehyde dehydrogenase gene (ALDH2 1/2 polymorphism) can influence the accumulation of acetaldehyde which may have a role in Alzheimer's disease (AD), and is widely prevalent among Mongoloids. Therefore ALDH2 1/2 polymorphism may represent a good candidate for genetic risk factors for AD, especially in East Asian. A case-control study from Japan found that ALDH2*2 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18201725
DOI: 10.1016/j.jns.2007.12.006

Genes

ALDH2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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