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Article

Merlin differentially associates with the microtubule and actin cytoskeleton

1 Feb 1998

Abstract excerpt

The neurofibromatosis 2 (NF2) suppressor gene encodes a protein termed merlin (or schwannomin) with sequence similarity to a family of proteins that link the actin cytoskeleton to cell surface glycoproteins. Members of this ERM family of proteins include ezrin, radixin, and moesin. These proteins contain a carboxyl (C-) terminus actin binding site. In contrast to the ERM proteins, merlin lacks the conventional...

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Identifiers

PMID: 9486775
DOI: 10.1002/(sici)1097-4547(19980201)51:3<403::aid-jnr13>3.0.co;2-7

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Merlin differentially associates with the microtubule and actin cytoskeletonPMID 9486775Read ↗

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.Semantic proximity Read ↗

The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene productSemantic proximity Read ↗

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