Merlin/Neurofibromatosis Type 2 Suppresses Growth by Inhibiting the Activation of Ras and Rac

Abstract excerpt

The small G-protein Ras is a tightly controlled regulator of cell fate. Prolonged or persistent arrest in the activated GTP-loaded state by mutation of Ras as in lung cancer or in a Ras-GTPase-activating protein as in neurofibromatosis type 1 promotes tumorigenesis. We now show that the tumor-suppressor protein merlin (mutated in neurofibromatosis type 2) also controls Ras activity. Systematic analysis of growth...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axon Guidance and Neuronal Signaling
• Share to Neuroblastoma Research and Treatments
• Share to Neurofibromatosis and Schwannoma Cases