Article
Merlin is a potent inhibitor of glioma growth.
Cancer research - 15 Jul 2008
Lau Ying-Ka Ingar, Murray Lucas B, Houshmandi Sean S, Xu Yin, Gutmann David H, Yu Qin
Abstract excerpt
Neurofibromatosis 2 (NF2) is an inherited cancer syndrome in which affected individuals develop nervous system tumors, including schwannomas, meningiomas, and ependymomas. The NF2 protein merlin (or schwannomin) is a member of the Band 4.1 superfamily of proteins, which serve as linkers between transmembrane proteins and the actin cytoskeleton. In addition to mutational inactivation of the NF2 gene in...
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