Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.

Article

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.

Oncogene - 1 Aug 1994

Takeshima H, Izawa I, Lee P S, Safdar N, Levin V A, Saya H

Abstract excerpt

The neurofibromatosis type 2 (NF2) gene was recently cloned, and the protein it encodes (merlin) was revealed to belong to a family of proteins that link cytoskeletal components with proteins in the cell membrane. To elucidate the biological function of merlin, we produced a bacterial fusion prot...

Topics

Base Sequence
Carrier Proteins
Cells, Cultured
Genes, Neurofibromatosis 2
Glutathione Transferase
Humans
Membrane Proteins
Molecular Sequence Data
Mutation
Neoplasm Proteins
Neurofibromin 2
Phosphorylation
Recombinant Fusion Proteins

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