Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.

Oncogene - 1 Aug 1994

Takeshima H, Izawa I, Lee P S, Safdar N, Levin V A, Saya H

Abstract excerpt

The neurofibromatosis type 2 (NF2) gene was recently cloned, and the protein it encodes (merlin) was revealed to belong to a family of proteins that link cytoskeletal components with proteins in the cell membrane. To elucidate the biological function of merlin, we produced a bacterial fusion protein consisting of glutathione S-transferase and merlin and used it to detect five merlin-binding cellular proteins,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carrier Proteins
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Molecular Sequence Data

Share to Mutation

Share to Phosphorylation

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 8035998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.PMID 8035998Read ↗

[Neurofibromatosis type 2 (NF2)].Semantic proximity Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read ↗

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations.Semantic proximity Read ↗

Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous systemSemantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

Neurofibromatosis 2: loss of merlin's protective spell.Semantic proximity Read ↗

NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.