Article
Modeling hepatic osteodystrophy in Abcb4 deficient mice.
Bone - 1 Aug 2013
Hochrath Katrin, Ehnert Sabrina, Ackert-Bicknell Cheryl L, Lau Yvonne, Schmid Andrea, Krawczyk Marcin, Hengstler Jan G, Dunn Jordanne, Hiththetiya Kanishka, Rathkolb Birgit, Micklich Kateryna, Hans Wolfgang, Fuchs Helmut, Gailus-Durner Valérie, Wolf Eckhard, de Angelis Martin Hrabě, Dooley Steven, Paigen Beverly, Wildemann Britt, Lammert Frank, Nüssler Andreas K
Abstract excerpt
Hepatic osteodystrophy (HOD) denotes the alterations in bone morphology and metabolism frequently observed in patients with chronic liver diseases, in particular in case of cholestatic conditions. The molecular mechanisms underlying HOD are only partially understood. In the present study, we characterized the bone phenotypes of the ATP-binding cassette transporter B4 knockout mouse (Abcb4(-/-)), a...
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