Article
Novel peptide-based vaccines efficiently prime murine "help"-independent CD8+ T cell responses in the liver.
Hepatology (Baltimore, Md.) - 1 Aug 2004
Dikopoulos Nektarios, Riedl Petra, Schirmbeck Reinhold, Reimann Jörg
Abstract excerpt
Vaccines for the prophylactic and/or therapeutic immunization against hepatotropic pathogens (e.g., hepatitis B and hepatitis C virus) should establish long-lasting, specific antiviral effector/memory CD8+ T cell immunity in the liver. We describe a novel peptide-based vaccine in which antigenic major histocompatibility complex Class I-binding peptides are fused to a cationic (e.g., human immunodeficiency virus...
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