Article
The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma.
Oncogene - 10 Jun 2004
Qiu Guo-Hua, Tan Luke K S, Loh Kwok Seng, Lim Chai Yen, Srivastava Gopesh, Tsai Sen-Tien, Tsao Sai Wah, Tao Qian
Abstract excerpt
Loss of heterozygosity at 3p21 is common in various cancers including nasopharyngeal carcinoma (NPC). BLU is one of the candidate tumor suppressor genes (TSGs) in this region. Ectopic expression of BLU results in the inhibition of colony formation of cancer cells, suggesting that BLU is a tumor suppressor. We have identified a functional BLU promoter and found that it can be activated by environmental stresses...
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