Article
High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma.
American journal of human genetics - 6 Jul 2023
Wang Tong-Min, Xiao Ruo-Wen, He Yong-Qiao, Zhang Wen-Li, Diao Hua, Tang Minzhong, Mai Zhi-Ming, Xue Wen-Qiong, Yang Da-Wei, Deng Chang-Mi, Liao Ying, Zhou Ting, Li Dan-Hua, Wu Yan-Xia, Chen Xue-Yin, Zhang Jiangbo, Li Xi-Zhao, Zhang Pei-Fen, Zheng Xiao-Hui, Zhang Shao-Dan, Hu Ye-Zhu, Cai Yonglin, Zheng Yuming, Zhang Zhe, Zhou Yifeng, Jin Guangfu, Bei Jinxin, Mai Hai-Qiang, Sun Ying, Ma Jun, Hu Zhibin, Liu Jianjun, Lung Maria Li, Adami Hans-Olov, Ye Weimin, Lam Tai-Hing, Shen Hongbing, Jia Wei-Hua
Abstract excerpt
Large-scale genetic association studies have identified multiple susceptibility loci for nasopharyngeal carcinoma (NPC), but the underlying biological mechanisms remain to be explored. To gain insights into the genetic etiology of NPC, we conducted a follow-up study encompassing 6,907 cases and 10,472 controls and identified two additional NPC susceptibility loci, 9q22.33 (rs1867277; OR = 0.74, 95% CI =...
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