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Article

Inactivation of LARS2, located at the commonly deleted region 3p21.3, by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma.

Acta biochimica et biophysica Sinica - 1 Jan 2009

Zhou Wen, Feng Xiangling, Li Hong, Wang Lei, Zhu Bin, Liu Weidong, Zhao Ming, Yao Kaitai, Ren Caiping

Abstract excerpt

Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% of primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been demonstrated to be involved in NPC development. LARS2 (leucyl-tRNA synthetase 2, mitochondrial) is...

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Share to Chromosomes, Human, Pair 3
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Silencing

Share to Nasopharyngeal Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sequence Deletion

Source

Identifiers

PMID: 19129950
DOI: 10.1093/abbs/gmn006

Genes

LARS2
LTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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