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Article

Stringent rosiglitazone-dependent gene switch in muscle cells without effect on myogenic differentiation.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 May 2004

Tascou Semi, Sorensen Tine-Kring, Glénat Valérie, Wang Manping, Lakich Mélissa M, Darteil Raphaël, Vigne Emmanuelle, Thuillier Vincent

Abstract excerpt

We have developed a gene switch based on the human transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) and its activation by rosiglitazone. However, ectopic expression of PPARgamma has been demonstrated to convert myogenic cells into adipocyte-like cells and, more generally, may interfere with the physiology of the target tissue. Consequently we modified the DNA-binding specificity...

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Identifiers

PMID: 15120324
DOI: 10.1016/j.ymthe.2004.02.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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