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Article

A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis.

The Journal of biological chemistry - 5 Sept 2008

Walkey Christopher J, Spiegelman Bruce M

Abstract excerpt

The nuclear hormone receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) is the central regulator of adipogenesis. Although it is the target for several drugs that function as agonist activators, a high affinity endogenous ligand for this receptor that is involved in regulating adipogenesis has yet to be identified. Here, we investigated the requirement for ligand activation of PPARgamma in fat...

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Identifiers

PMID: 18622018
DOI: 10.1074/jbc.C800139200
PMCID: PMC2529017

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